Evidence for the hydrolysis of topical applied liposomal lipids in human stratum corneum.
نویسنده
چکیده
Liposomes were incubated with an extract of human plantar stratum corneum. The liposomal lipids were hydrolysed, if composed of soy-bean phosphatidylcholine or phosphatidylglycerol. Rigid lipids were not degraded. The temperature optimum of the hydrolysis was between 30-35degC. CaCl enhanced, while EDTA reduced the rate of hydrolysis, indicating that the hydrolysis is due to a phospholipase A(2).
منابع مشابه
Short Communication EVIDENCE FOR THE HYDROLYSIS OF TOPICAL APPLIED LIPOSOMAL LIPIDS IN HUMAN STRATUM CORNEUM
Liposomes were incubated with an extract of human plantar stratum corneum. The liposomal lipids were hydrolysed, if composed of soy-bean phosphatidylcholine or phosphatidylglycerol. Rigid lipids were not degraded. The temperature optimum of the hydrolysis was between 30-35°C. CaCl2 enhanced, while EDTA reduced the rate of hydrolysis, indicating that the hydrolysis is due to a phospholipase A2.
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ورودعنوان ژورنال:
- Cellular & molecular biology letters
دوره 7 2 شماره
صفحات -
تاریخ انتشار 2002